Acquisition setting optimization and quantitative imaging for I studies with the Inveon microPET-CT system

نویسندگان

  • Nadège Anizan
  • Thomas Carlier
  • Cecilia Hindorf
  • Jacques Barbet
چکیده

Background: Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positronemission tomography [PET] isotopes such as I is promising in that context but requires accurate activity quantification. The decay scheme of I implies an optimization of both acquisition settings and correction processing. The PET scanner investigated in this study was the Inveon PET/CT system dedicated to small animal imaging. Methods: The noise equivalent count rate [NECR], the scatter fraction [SF], and the gamma-prompt fraction [GF] were used to determine the best acquisition parameters for mouseand rat-sized phantoms filled with I. An image-quality phantom as specified by the National Electrical Manufacturers Association NU 4-2008 protocol was acquired and reconstructed with two-dimensional filtered back projection, 2D ordered-subset expectation maximization [2DOSEM], and 3DOSEM with maximum a posteriori [3DOSEM/MAP] algorithms, with and without attenuation correction, scatter correction, and gamma-prompt correction (weighted uniform distribution subtraction). Results: Optimal energy windows were established for the rat phantom (390 to 550 keV) and the mouse phantom (400 to 590 keV) by combining the NECR, SF, and GF results. The coincidence time window had no significant impact regarding the NECR curve variation. Activity concentration of I measured in the uniform region of an image-quality phantom was underestimated by 9.9% for the 3DOSEM/MAP algorithm with attenuation and scatter corrections, and by 23% with the gamma-prompt correction. Attenuation, scatter, and gamma-prompt corrections decreased the residual signal in the cold insert. Conclusions: The optimal energy windows were chosen with the NECR, SF, and GF evaluation. Nevertheless, an image quality and an activity quantification assessment were required to establish the most suitable reconstruction algorithm and corrections for I small animal imaging.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Acquisition setting optimization and quantitative imaging for 124I studies with the Inveon microPET-CT system

Background: Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positronemission tomography [PET] isotopes such as I is promising in that context but requires accurate activity quantification. The decay scheme of I implies an optimization of both ...

متن کامل

dAcquisition setting optimization and quantitative imaging for 124I studies with the Inveon microPET-CT system

BACKGROUND Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positron-emission tomography [PET] isotopes such as 124I is promising in that context but requires accurate activity quantification. The decay scheme of 124I implies an optimization of...

متن کامل

Computed tomography based attenuation correction in PET/CT: Principles, instrumentation, protocols, artifacts and future trends

  The advent of dual-modality PET/CT imaging has revolutionized the practice of clinical oncology, cardiology and neurology by improving lesions localization and the possibility of accurate quantitative analysis. In addition, the use of CT images for CT-based attenuation correction (CTAC) allows to decrease the overall scanning time and to create a noise-free attenuat...

متن کامل

A dedicated high-resolution PET imager for plant sciences.

PET provides an in vivo molecular and functional imaging capability that could be valuable for studying the interaction of plants in changing environments at the whole-plant level. We have developed a dedicated plant PET imager housed in a plant growth chamber (PGC), which provides a fully controlled environment. The system currently contains two types of scintillation detector modules from com...

متن کامل

Comparison of transient ischemic dilation ratios in SPECT and SPECT-CT myocardial perfusion imaging in the low pre-test probability group

Introduction: The main purpose of this study was to compare transient ischemic dilation (TID) ratios in SPECT-low dose CT and SPECT Myocardial Perfusion Imaging (MPI) by application of different quantitative programs and quantify the possible shift in the upper normal limits of TID ratio in the SPECT-CT MPI. Methods: 149 Patients with low pre-test probability for coronary artery disease (CAD),...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012